Author: Leo
Keywords: kidney damage | cells | Renal | acute
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According to a recent paper published in Cell Reports, cells injured in the kidneys can enter the repair mode by means of the Sox9 gene being knocked in.
According to a recent paper published in Cell Reports, cells injured in the kidneys can enter the repair mode by means of the Sox9 gene being knocked in.
Sanjeev Kumar MD is the first author, he is a postdoctoral research assistant at the University of Southern California's Keck School of Medicine, at the AndyMcMahon Laboratory, where he is a Ph.D., Dean and Professor. Professor w.m.Keck is a professor of stem cell biology and regenerative medicine at the Keck School. He found that surviving damaged cells could start the Sox9 gene, a stressful response to kidney damage. The regenerated damaged cells are in the inner layer of the kidney, the kidney is the functional unit of the kidney, can quickly repair acute kidney injury (AKI).
By recruiting most of the surviving epithelial cells to help repair the severely injured organ in time, the kidney's Sox9 gene-initiated repair is associated with stem cell repair methods in many other organs.
"At present, the treatment of acute renal injury itself does not exist.To cure acute renal injury in the kidney, to determine the internal mechanism of repair of the kidney is essential, serious illness in hospital mortality rate will be more than 50%." Kumar said.
Some of the kidneys were unable to repair, and Sox9 remained active to define the area of the ineffective repair response. Further challenge to these areas can provide an important link between acute kidney injury and its transition to chronic and advanced kidney disease.
Sox9 also plays a key role in the normal development of the kidneys.
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