Author: Leo and Lucy
Keywords: renal function
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New ways to predict renal function can improve chemotherapy dose. Cambridge University scientists have developed a new statistical model that can estimate the renal function of cancer patients. This is the most accurate model for estimating that renal function has not yet been developed and should help cancer specialists treat patients more safely and improve the accuracy of chemotherapy doses.
The kidneys perform some important functions, including filtering waste and toxins from the blood, producing vitamin D and regulating blood pressure. The renal filtration function was measured by glomerular filtration rate (GFR), blood flow through the glomerular blood rate, and small blood vessel filters in the kidneys.
The determination of GFR is important because the assessment of renal function can indicate the progress of the disease, whether the drug treatment has adverse side effects on the critical body function, and if the prescription can be safe at a given dose, it is particularly important for the cancer physician to open the chemotherapeutic agent The problem. However, it is technically difficult to measure GFR. Therefore, doctors often rely on the estimated GFR method, which may be more inaccurate.
"Almost every patient with cancer can measure their renal function, according to GFR estimates, this value affects many treatment decisions, but so far we do not know the best way to provide this value for cancer patients." From British Cancer Institute (CRUK) Associate author of Tobias Janowitz, Cambridge University. "Given the importance of this measure in routine clinical practice, we believe that we should provide evidence-based models for this calculation in this context."
Now, in a study published today in the Journal of Clinical Oncology, the authors describe a new and better way to estimate GFR, which was developed using data from large data from more than 2,500 patients. They use the GFR accurate measurement to provide the gold standard, and then use the statistical modeling method to find the best mathematical model to estimate the GFR. The new model also provides a measure of the uncertainty of this estimate.
To test the use of this revised GFR estimation method, the investigators focused on the accuracy of chemotherapy doses, particularly carboplatin, for the treatment of various cancers such as lung cancer, germ cell tumors, ovarian cancer and breast cancer The The new model significantly reduces the likelihood of carboplatin improper administration compared to the models currently used in clinical practice.
The accuracy of chemical dosages is very important, "says Edward Williams," The first author of the joint is also from the CRUK Cambridge Institute. "Excessive chemotherapy may be toxic and may even be life-threatening, but chemotherapy may be ineffective for cancer, and our model should To help doctors more accurately calculate the dose of chemotherapy, thereby reducing the risk of toxicity or treatment failure.
The model is available online for clinicians.
"We believe that this rigorous method-based tool may have a positive impact on the care of many cancer patients," said Professor Helena Earl, a senior author at the University of Cambridge, Department of Oncology. "That's why we make it free and easy to access. "
"The limit we know best about working is that because of our patient data on the data set, our model does not provide guidance on the impact of races on the estimated GFR, although it is well known that races can be key variables," Dr. Janowitz explains Say. "This will be resolved in the future work, we are also keen to explore the new model of cancer outside the performance of patients with disease.
"This work is a good example of the combination of scientists from different professions for the care of cancer patients."
The study was supported by the British Cancer Institute, the Wellcome Trust and the National Institutes of Health Cambridge Biomedical Research Center.
"Chemotherapy is very powerful, so using the right dose will make a big difference in its effectiveness and how to avoid unnecessary side effects, which can measure that the patient's kidneys are working," says Peter Johnson, chief clinician at the British Cancer Institute. Such as carboplatin left the body's speed to help make our treatment more accurate and more suitable for everyone.
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