Author: Leo and Lucy
Keywords: dialysis | carnitine
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| From google images |
Carnitine: • L-carnitine is a necessary substance for human energy metabolism; • There are many factors in hemodialysis patients, including reduced intake, reduced synthesis and dialysis clearance, resulting in carnitine deficiency, acyl carnitine accumulation; • In hemodialysis Patients, supplementation of L-carnitine is conducive to correct anemia, reduce dialysis in low blood pressure, improve skeletal muscle function and improve heart function.
Hello, everyone!
I am a carnitine lady, you may not know me, I will be a self-introduction it I am a water-soluble small molecule, the chemical structure is 3-hydroxy-4-trimethylaminobutyric acid, molecular weight of only 162.2 daltons.
I am a member of the vitamin family. The so-called vitamins, is necessary to maintain the health of a class of organic compounds, such substances in the body is neither the body's raw materials, nor the source of energy, but a class of regulatory substances, plays an important role in material metabolism.
Our substance can not be synthesized or synthesized because of the lack of quantity in the human body, so it is often necessary to supply food. Like me, 25% is your own body synthesis, the other 75% is produced by exogenous food metabolism.
Usually carnitine which will be hidden in the food?
I like fleshy, so in red meat, such as lamb and beef the highest content (content of 203mg / 100g and 61mg / 100g), followed by pork (27mg / 100g). And then milk Yeah, eggs, the content is much lower. I do not like vegetables, so in cabbage, carrots can not find me Oh! So, if you want to add enough carnitine, you must eat red meat! (But if it is hemodialysis patients, every day can eat red The amount of meat is limited, you must listen to the guidance of health care Oh!)
Why add carnitine?
Do not underestimate my little body, the role is very strong, the body a lot of physiological functions are inseparable from my help Oh!
1. Carrying long chain fatty acids into mitochondria involved in beta oxidation and energy generation (fatty acids are energy substrates for all tissues except the brain);
2. Eliminate intracellular acyl groups, release the accumulation of long chain acyl groups on the toxicity of cells;
3. regulate the balance of mitochondrial lactase coenzyme A and coenzyme A;
4. Stabilize cell membrane to protect endothelial function.
What if carnitine is not enough?
Here I have to mention a disease that is closely related to me, DCD (Dialysis-related Carnitine Deficiency) - dialysis-related L-carnitine deficiency (note that L-Carnitine is my alias) Because of hemodialysis caused by the lack of secondary L-carnitine. DCD can cause a variety of clinical manifestations, such as low reactivity of erythropene, dialysis between hypotension, cardiomyopathy and fatigue as a prominent performance of skeletal muscle dysfunction and so on (vernacular, is anemia, hypotension, chest tightness, chest pain , Fatigue, cramps, etc.). These complications not only affect the quality of life of dialysis patients, but also affect the patient's dialysis treatment process, increased the burden of hospital and medical staff. Therefore, it is very important to control the occurrence of these complications.
For patients with hemodialysis, the emphasis is placed on the cause of the disease
Because the dialysis patients often poor appetite or some suffering from chronic gastropathy, resulting in dietary structure of meat is relatively small, lack of carnitine intake; In addition, because of renal insufficiency, body carnitine synthesis; Finally, I just talked that he was a little man, but also water-soluble, so, with the dialysis treatment, I lost. Studies have shown that every time I dialysis, I will lose 68% of the companion it, over time, dialysis patients carnitine levels are getting lower and lower. Remember, not just the loss of carnitine in the plasma, carnitine in skeletal muscle also ran away.
Email:kdtinchina@yahoo.com
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