Author: Leo
Keywords: uremia
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| From google images |
Uremia can be said that the last stage of kidney disease, people have a deep fear of uremia, then, how is the cause of uremia?
1
Diabetic nephropathy
30% to 50% of diabetic patients may be involved in the kidney. Diabetic patients due to lack of insulin secretion in the body, resulting in sugar, fat metabolism disorders. High glucose state, glomerular capillary endothelial cell damage, causing renal inflammation, involving the renal tubules, renal interstitial, so that glomerular sclerosis, renal tubules and renal interstitial fibrosis, renal function gradually lost, Eventually causing uremia. This pathological change process is often a strong occult, early asymptomatic, often missed the best time to treat, and once into the duration of continuous proteinuria, 50% of patients in 10 years into the uremic period.
2, hypertensive nephropathy
15% of hypertensive patients will be directly converted to uremia. Long-term high blood pressure to the glomerular ball arterial pressure increases, glomerular hyperbaric, leading to capillary endothelial cell damage, start the process of renal fibrosis. And renal insufficiency, the state of ischemia and hypoxia will further aggravate high blood pressure. Once the vicious cycle of the two start, in a certain time that is uremia.
3
Urinary tract infection
Urinary tract infection such as improper treatment, not only can cause stones, but also cause retrograde infection of the bacteria, the same can affect the renal pelvis, renal tubules, renal interstitial, and thus the glomerular vascular endothelial cell damage, damage the kidney unit, affecting renal function The progressive decline caused by uremia.
4, primary glomerular disease
Primary glomerular disease
title
Refers to a variety of causes caused by bilateral renal diffuse or focal glomerular lesions can be divided into acute, rapid and chronic, to uremia time is also different. Acute glomerulonephritis is only a small part of patients with acute renal failure or the development of chronic glomerulonephritis; part of the radical glomerulonephritis patients can be cured or controlled, the other part of the progress in different times for uremia; Chronic glomerulonephritis in the clinical manifestations of proteinuria, hematuria and so on.
This type of kidney disease in patients with early asymptomatic, the disease is often not attention, resulting in the process of renal fibrosis started, the disease is often no special effective treatment, resulting in the degree of progressive fibrosis, renal function gradually lost, Eventually leading to fibrosis of the scar tissue formation, into the uremic period.
5
drug
Drugs of varying degrees of side effects can also cause renal failure, and ultimately the development of uremia. Commonly used for the analgesic nephropathy, refers to long-term use of analgesics (aspirin, acetaminophen, etc.) caused by chronic renal tubular - interstitial nephritis, especially in the original kidney disease based on the use of such drugs, can increase kidney disease Progress.
6, other systemic systemic disease
Such as systemic lupus erythematosus, allergic purpura, rheumatoid arthritis, systemic hard ANCA-associated vasculitis, myeloma, Sjogren's syndrome, etc. will be affected by renal vascular or renal parenchyma caused by uremia.
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