Author: Leo
Keywords: lupus nephritis
Lupus nephritis (LN) is a common complication of systemic lupus erythematosus (SLE), accounting for 13.5% of renal biopsy patients, is the most common secondary glomerulonephritis in China. 11.1% of LN patients eventually progress to end-stage renal disease (ESRD), requiring renal replacement therapy.
In 1975, the United States successfully implemented the first case of LN patients with renal transplant surgery, LN-ESRD patients with a new treatment options. Foreign reported LN patients after renal transplantation, LN recurrence rate of about 1.8% to 54%, on the survival rate of human and kidney reports vary. At present, domestic research in this area is rare, there are only one report on the long-term prognosis of LN renal transplantation. This review retrospectively analyzed the clinical characteristics and long-term prognosis of LN patients undergoing renal transplantation and compared them with non-LN patients receiving renal transplantation at the same time.
Second, the research object
Screening from March 1994 to December 2014 Nanjing Military Region, Nanjing General Hospital of renal transplantation in 1812 cases of renal transplantation. (2) renal biopsy confirmed LN or urine abnormalities (proteinuria, hematuria) or serum creatinine (SCr) increased; (3) follow-up time ≥ 6 months; (4) ) Renal survival rate ≥ 3 months; (5) Han nationality. The control group selected non-LN patients who underwent renal transplantation at the same time, and randomly matched the transplant time, sex and age. The matching ratio was 1: 4.
In this study, 18 patients were included, including 5 males and 13 females, with an average age of 33 ± 7 years for renal transplantation. 18 patients were involved in the kidney, extrahepatic organ damage as follows: 11 cases of joints, 11 cases of skin, 7 cases of blood system, serous cavity in 1 case. Fifteen patients had complete remission or partial remission after hormone and immunosuppressive therapy. 2 patients had never been relieved by hormone therapy and 1 patient had mild remission. The median time from diagnosis of LN to ESRD was 59.5 (24 ~ 94.5) months, and the median time was 13 (4 ~ 22.3) months. There was no difference between the two groups.
A total of 72 patients were enrolled in the control group, including 20 males and 52 females with an average age of 33 ± 7 years for renal transplantation. The primary disease includes 10 cases of IgA nephropathy, 2 cases of focal segmental glomerulosclerosis, 2 cases of polycystic kidney disease, 1 case of primary aldosteronism, 1 case of systemic vasculitis, 1 case of membranous nephropathy, 55 cases of unknown cause.
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