Author: Leo
Keywords: lupus nephritis
Six months after renal transplantation: There was no statistically significant difference in SCr and urinary protein between the two groups. LN group of 11 patients received autoantibody examination, 9 cases (81.8%) ANA positive, Ads-DNA were negative.
The median follow-up time was 52.8 (33.6 ~ 88.4) months in the LN group and 58.5 (34.1 ~ 110.1) months in the control group. There was no statistically significant difference in the incidence of acute rejection, chronic rejection, cardiovascular events, infection and tumor progression during follow-up.
LN group 1 case (5.6%) patients with LN recurrence. The patients after renal transplantation to "prednisone + cyclosporine A + or mycophenolate mofetil" triple immunosuppressive therapy, renal function returned to normal, 6 months after transplantation routine renal biopsy, the pathological tips of renal transplantation Interstitial rejection, but no corresponding clinical symptoms, to anti-rejection drug treatment, urine protein was negative, normal renal function, SCr stable at 70.7μmol / L or so, complement normal, ANA negative. In patients with renal transplantation 54 months after the urine protein positive, SCr increased to 132.6μmol / L, renal biopsy prompted the existence of chronic renal transplantation on the basis of acute rejection, to methylprednisolone treatment for three days, follow-up to "hormone + Tacrolimus + rapamycin "after treatment, repeated review of lupus indicators, suggesting that complement decreased, Ads-DNA negative, ANA titer gradually increased (up to 1:128), excluding other possible factors, consider Lupus and then to the "hormone + tacrolimus + mycophenolate mofetil" treatment, urine protein negative, SCr stable at 106.1μmol / L or so, complement back to normal, ANA negative.
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